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In vitro regulation of B cell differentiation by interleukin-6 and soluble CD23 in systemic lupus erythematosus B cell subpopulations and antigen-induced normal B cells

✍ Scribed by David J. Klashman; Robert A. Martin; Ronald H. Stevens; Otoniel Martínez-Maza

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
987 KB
Volume
34
Category
Article
ISSN
0004-3591

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✦ Synopsis

Polyreactive systemic lupus erythematosus (SLE) B cells were compared with antigen-induced SLE and normal B cells for their interleukin-6 (IL-6) and soluble CD23 requirements. Unlike normal B cells, secretion of antibody by SLE B cells in serum-free medium was not enhanced by exogenous IL-6. Anti-IL-6 antibodies inhibited immunoglobulin production in cultures of normal and SLE B cells, which suggests that IL-6 is required for B cell differentiation. SLE culture supernatants had elevated levels of IL-6, which explains the poor response of the SLE cells to exogenous IL-6. Soluble CD23 enhanced the responses of cells from normal subjects and SLE patients.

Systemic lupus erythematosus (SLE) is an autoimmune condition that results in multiple organ damage, presumably, because of autoantibodymediated and/or immune complex-mediated destruction of cells. A major immunologic feature of SLE is From the Division of Rheumatology, Department of Medicine,

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