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Heterogeneity of the spontaneously expanded and mitogen-induced generation of suppressor cell function of t cells on b cells in systemic lupus erythematosus

✍ Scribed by Alejandro Ruiz-Arguelles; Donato Alarcón-Segovia; Luis Llorente; JOSéa Del Guidice-Knipping

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
579 KB
Volume
23
Category
Article
ISSN
0004-3591

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✦ Synopsis

Abstract

Eighty percent of 31 untreated patients with systemic lupus erythematosus (SLE) and abnormalities in their spontaneously expanded and/or Con‐A‐induced suppressor cell function, but the association of defects detected with both systems was only 68%. Loss of spontaneous suppression related positively to disease activity (r = 0.641) and the number of T~γ~ cells (r = 0.624) whereas Con‐A‐induced suppression correlated negatively with disease activity (r = ‐0.456) and the number of T~γ~ cells (r = ‐0.089). Incubation of mononuclear cells from SLE patients in antiribonucleoprotein IgG caused further loss of suppression in some, but not all, instances. The suppressor cell dysfunction found in SLE may result from diverse mechanisms, including a basic defect in the generation of suppressor cells and the abrogation of suppressor function by autoantibodies.

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