Immunochemical and biochemical study of a human Fcμ fragment (μ-chain disease)

✍ Scribed by J. P. Lebreton; C. Ropartz; J. Rousseaux; P. Roussel; M. Dautrevaux; G. Biserte

• Book ID: 102822396
• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: English
• Weight: 736 KB
• Volume: 5
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830050306

✦ Synopsis

Abstract

An abnormal protein, from a patient with μ‐chain disease has been studied: protein BUR. It is devoid of the F(ab″)~2μ~ fragment; molecular weight determinations and immunological data identify the protein as a F(c)~5μ~ fragment. Similarly, carbohydrate determinations and proteolysis experiments relate it to a Fcμ fragment. Nevertheless, the protein, which contains J‐chain, lacks the entire covalently bonded structure of the F(c)~5μ~ fragment. C‐terminal analysis shows a tyrosine residue identical to the C‐termin amino acid of μ‐chains. Sequence of the N‐terminal region determined for 15 residues shows identity with sequence 338–352 and sequence 333–347 of two entire μ‐chains previously studied. The relation of BUR to other heavy chain disease proteins is discussed.