Physicochemical and immunological properties of a μ chain disease protein
✍ Scribed by C. Mihaesco; Edith Mihaesco; R. Miglierina; J. Lamaziere; J.P. Roy; M. Seligmann
- Book ID
- 115942874
- Publisher
- Elsevier Science
- Year
- 1976
- Weight
- 974 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0019-2791
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## Abstract An abnormal protein, from a patient with μ‐chain disease has been studied: protein BUR. It is devoid of the F(ab″)~2μ~ fragment; molecular weight determinations and immunological data identify the protein as a F(c)~5μ~ fragment. Similarly, carbohydrate determinations and proteolysis exp
## Abstract Heavy chain diseases (HCD) are neoplastic proliferations of B cells which secrete truncated immunoglobulin heavy chains without associated light chains. These proteins are encoded by mutated genes which may also give rise to truncated membrane immunoglobulins. The neoplastic cells proli