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A pre-translational defect in a case of human μ heavy chain disease

✍ Scribed by Ajay Bakhshi; Paul Guglielmi; John E. Coligan; Frank Gamza; Thomas A. Waldmann; Stanley J. Korsmeyer

Book ID
119089591
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
922 KB
Volume
23
Category
Article
ISSN
0161-5890

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## Abstract Heavy chain diseases (HCD) are neoplastic proliferations of B cells which secrete truncated immunoglobulin heavy chains without associated light chains. These proteins are encoded by mutated genes which may also give rise to truncated membrane immunoglobulins. The neoplastic cells proli