Immunization for Ebola virus infection
โ Scribed by Xu, Ling; Sanchez, Anthony; Yang, Zhi-Yong; Zaki, Sherif R.; Nabel, Elizabeth G.; Nichol, Stuart T.; Nabel, Gary J.
- Book ID
- 109926827
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 729 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1078-8956
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Six rhesus and two vervet monkeys were infected intraperitoneally with Ebola virus. They developed an acute haemorrhagic fever with skin rash 4 days later and died 6--12 days after infection. Histopathological lesions of acute necrosis were present in the liver, spleen, lymph nodes, lungs and testes
When Ebola virus was first isolated in our laboratory [Pattyn et al, 19771 we had observed that baby mice died after intracerebral inoculation of virus contair,ing human serum. At that time brains were harvested and forwarded to the Microbiological Research Establishment, Porton UK, where a suspensi