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Immunization against the polyoma tumor-specific transplantation antigen (TSTA) with polyoma T-antigens

✍ Scribed by T. Ramqvist; D. O. Pallas; J. Deanda; L. Ährlund-Richter; G. Reinholdsson; T. M. Roberts; B. S. Schaffhausen; T. Dalianis

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
648 KB
Volume
42
Category
Article
ISSN
0020-7136

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✦ Synopsis

The relationship between the pol yoma virus tumor-specific transplantation antigen (TSTA) and 2 of the virus proteins coded from the early region of polyomavirus was investigated. Mice were immunized with small T antigen and a truncated mutant of middle T antigen, both purified from genetically engineered Escherichia coli. The 2 proteins induced protective immunity against polyomavirus-induced tumors, but not against non-polyoma tumors, indicating that one or more of the polyoma T antigens are directly involved in a TSTA function.

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