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Studies on the polyoma tumor-specific transplantation antigen (TSTA): Selection and characterization of TSTA-negative segregants from somatic hybrids

✍ Scribed by Torbjörn Ramqvist; Git Reinholdsson; Robert Szigeti; George Klein; Tina Dalianis

Publisher: John Wiley and Sons
Year: 1987
Tongue: French
Weight: 790 KB
Volume: 40
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910400114

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✦ Synopsis

Two polyoma-TSTA-negative variants were selected independently from a polyoma fibrosarcomdMoloney lymphoma somatic hybrid, by repeated passages in polyoma-virus-preimmunized mice. One of the variants had lost all its polyoma DNA, while the other only retained a deleted piece of its integrated polyoma D N A . In contrast to the parental hybrid clone, none of the variants produced detectable amounts of T-antigens. This finding indicates that a detectable expression of the products of the polyoma virus early genome, the Tantigens, is important either directly or indirectly for the expression of TSTA.

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✍ Tina Dalianis; Torbjörn Ramqvist; George Klein 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 347 KB

Mice and rats could be immunized against the polyoma-virus-induced tumor-specific transplantation antigen (TSTA) by repeated inoculation of frozen or irradiated cells of an MT-cDNA-transformed rat cell line (2.8) that contains only the polyoma middle T-antigen, or by cells that carried a host range