✦ LIBER ✦

Immune-mediated peripheral neuropathies and voltage-gated sodiums channels

✍ Scribed by Michael Benatar; Hugh J. Willison; Angela Vincent

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 94 KB
Volume: 22
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199901)22:1<108::aid-mus16>3.0.co;2-i

No coin nor oath required. For personal study only.

✦ Synopsis

Antibodies to GM 1 ganglioside are found in some patients with the Guillain-Barre ´syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by 22 Na + influx in a motor neuronal cell line (NSC19) in which we demonstrated GM 1 ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cells.

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