Immobilized liposome chromatography of drugs for model analysis of drug-membrane interactions
β Scribed by Per Lundahl; Farideh Beigi
- Book ID
- 114176392
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 675 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0169-409X
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π SIMILAR VOLUMES
We studied the effect of charged lipids or detergent on the retention of drugs and an oligonucleotide by immobilized liposome chromatography to characterize solute-membrane interactions. This is a novel approach in analysis of oligonucleotide-liposome interactions. The charged lipids (phosphatidylse
Water-oil transfer free energies calculated according to the values given in Table 1 of Ref. 20. Since the insertion of charged terminal groups into the hydrophobic layers of membrane is unfavorable (21) and probably did not occur in ILC, the values for the amino group \((5.0 \mathrm{kcal} / \mathrm