Use of immobilized artificial membrane chromatography for drug transport applications
β Scribed by Barbra H. Stewart; O. Helen Chan
- Book ID
- 109389150
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 225 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
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## Abstract This study reports a rapid screening method for the prediction of oral drug bioavailability in humans based on combined immobilized artificial membrane (IAM) chromatographic capacity factor (__k__~IAM~) and __in vitro__ stability in hepatic microsomes. The fraction of drug absorbed (__F
## Abstract The relationship between the logarithm of retention indices (log __k__~IAM~) of 55 diverse drugs in immobilized artificial membrane (IAM) chromatography and molecular structure descriptors was established by linear and nonβlinear modeling methods β Projection Pursuit Regression (PPR) an