Imipramine serum protein binding in healthy subjects
β Scribed by Kristensen, Christian Bruun
- Book ID
- 109843268
- Publisher
- Nature Publishing Group
- Year
- 1983
- Tongue
- English
- Weight
- 388 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0009-9236
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Mianserin protein binding was measured in serum from 43 healthy subjects and plasma from 12 elderly depressed patients and 23 patients with rheumatoid arthritis. Free fraction (mean +/- SD) was 5.5 +/- 0.7% in the healthy subjects, 5.0 +/- 0.8% in the elderly subjects and 6.0 +/- 1.0 in the patients
Forty-eight hours after a single dose of 14C-imipramine to rats, 14Cradioactivity could be measured in the following organs: liver > kidney > serum > fat > spleen > duodenum > lung > muscle and brain. Liver microsomes contained the main part of radioactivity derived from '4C-imipramine. After exhau