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Iminosugar Analogues of Phosphatidyl Inositol as Potential Inhibitors of Protein Kinase B (Akt)

โœ Scribed by Alexandre Orsato; Emanuela Barbagallo; Barbara Costa; Sandro Olivieri; Luca De Gioia; Francesco Nicotra; Barbara La Ferla


Book ID
102831415
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
576 KB
Volume
2011
Category
Article
ISSN
1434-193X

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Synthesis of diacylglycerol analogues as
โœ Josie C. Briggs; Alan H. Haines; Richard J.K. Taylor; Alan P. Dawson; I. Gibson; ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 973 KB

A series of analogues of diacylglycerol has been prepared and tested as inhibitors of protein kinase C (PKC). The diketone analogues, 10-hydroxymethyl-8,13-eicosanedione (24), 10-acetoxymethyl-8,13-eicosanedione (25), and 10-methoxymethyl-8,13-eicosanedione (26) each inhibited PKC activated by 2-O-a