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Imaging time-of-flight secondary ion mass spectrometry of solid-phase peptide syntheses

✍ Scribed by Aubagnac, J.-L.; Enjalbal, C.; Drouot, C.; Combarieu, R.; Martinez, J.

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 430 KB
Volume: 34
Category: Article
ISSN: 1076-5174
DOI: 10.1002/(sici)1096-9888(199907)34:7<749::aid-jms828>3.0.co;2-p

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✦ Synopsis

Imaging time-of-flight secondary ion mass spectrometry (TOF-SIMS) of solid-phase peptide syntheses carried out by the Merrifield and Sheppard strategies is described. Mixtures of resin beads mixed at random from batch syntheses or obtained in combinatorial chemistry by the mix and split technique, where each bead is functionalized by a unique peptide, were analyzed directly without any chemical cleavage of the growing chains to assess the nature of the growing structure on any bead of the mixture without its isolation.

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