Imaging studies and APOE genotype in persons at risk for Alzheimer’s disease
✍ Scribed by Nikolaos Scarmeas; Yaakov Stern
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 122 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1523-3812
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The apolipoprotein E (ApoE) genotype is a significant risk factor and modulator of age of onset of Alzheimer's disease (AD). We analyzed the effect of the ApoE genotype in two distinct early-onset familial AD groups: families with a mutation in the presenilin-1 gene (PS-1) on chromosome 14, and fami
## Abstract ## Objective Virtually all adults with Down syndrome (DS) have neuropathological manifestations of Dementia in Alzheimer's disease (DAD) but not all develop clinical psychopathology. The effect of allelic variants of Apolipoprotein (APOE) gene in development and progression of DAD and
## Abstract ## Objective The association between the APOE __ε__4 allele and depression was investigated in a retrospective study of 323 AD patients. ## Methods Patients were divided into demographically comparable groups based on the presence or absence of depression. ## Results Results showed