APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study

✍ Scribed by Lisa Delano-Wood; Wes S. Houston; Jennifer A. Emond; Natalie L. Marchant; David P. Salmon; Dilip V. Jeste; Leon J. Thal; Mark W. Bondi

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 89 KB
• Volume: 23
• Category: Article
• ISSN: 0885-6230
• DOI: 10.1002/gps.1953

✦ Synopsis

Abstract

Objective

The association between the APOE __ε__4 allele and depression was investigated in a retrospective study of 323 AD patients.

Methods

Patients were divided into demographically comparable groups based on the presence or absence of depression.

Results

Results showed that the frequency of APOE __ε__4 allele was significantly higher in the depressed vs non‐depressed AD patients (72% and 58%, respectively), and an interaction revealed that women possessing the APOE __ε__4 allele were almost four times more likely to be depressed than those without the __ε__4 allele.

Conclusion

Results are consistent with recent suggestions that the APOE __ε__4 genotype may be over‐represented among depressed women with AD and highlight the need for additional research investigating the links between APOE genotype, mood, and gender. Copyright © 2007 John Wiley & Sons, Ltd.