IL-10 is required for human CD4+CD25+ regulatory T cell-mediated suppression of xenogeneic proliferation
✍ Scribed by Yi, Shounan; O'Connell, Philip J; Sun, Lei
- Book ID
- 109865993
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 87 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0818-9641
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📜 SIMILAR VOLUMES
CD28 and CTLA-4 are opposing regulators of T cell activation, triggered by the two ligands CD80 and CD86. How these ligands promote either T cell activation via CD28 or inhibition via CTLA-4 is not understood. Using CD80 and CD86 molecules expressed on transfected cells, we have identified a major d
## Abstract ## Objective We previously demonstrated that CD4+,CD25+ regulatory T (Treg) cells are present in increased numbers in the synovial fluid (SF) of rheumatoid arthritis (RA) patients and display enhanced suppressive activity as compared with their peripheral blood (PB) counterparts. Despi