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IL-1 MODIFIES SYSTEM A TRANSPORT ACTIVITY IN HUMAN RHEUMATOID SYNOVIAL CELLS

✍ Scribed by VALÉRIE LE MAIRE; ALAIN HERNVANN; HERVÉ LE MARECHAL; OHVANESSE G EKINDJIAN; CHRISTIAN AUSSEL

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
168 KB
Volume
21
Category
Article
ISSN
1065-6995

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✦ Synopsis

Abstract

Given the importance of interleukin‐1 in both rheumatic diseases and the modulation of cell metabolic activities, we studied the action of this cytokine on the neutral amino acid transport A system on rheumatoid synovial cells. In these cells IL‐1 (1ng/ml) induced amino transport stimulation from 5min to 5h. This effect was obtained only after a starvation period. No concentration‐related effect was found for IL‐1‐stimulated MeAIB uptake, and the IL‐1‐mediated MeAIB uptake stimulation is independent of protein synthesis. Neosynthesis or post‐translational maturation of protein transport is a prerequisite for obtaining this effect. In conclusion, rheumatoid synovial cells exhibit a higher sensitivity for IL‐1 than osteoarthritic ones, probably related to their intense metabolic activity.

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