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Dependence of adaptative regulation for IL-1β action on system A activity in human synovial cells

✍ Scribed by Valérie Le Maire; Alain Hernvann; Michel Vaubourdolle; Ohvanesse G. Ekindjian; Christian Aussel


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Volume
168
Category
Article
ISSN
0021-9541

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✦ Synopsis


Human synovial cells


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System a neutral amino acid transporter
✍ Valérie Le Maire; Egle Solito; Françoise Russo-Marie; Alain Hernvann; Hervé Le M 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 275 KB 👁 1 views

We studied the long-terms effects of interleukin-1beta (IL-1beta; 3 to 6 h) on alpha-(methylamino) isobutyric acid (MeAIB), a nonmetabolizable amino acid transported by system A. We found that IL-1beta induced a large decrease in MeAIB uptake by human osteoarthritic synovial cells and a concomitant