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IKKϵ Signaling: Not Just NF-κB

✍ Scribed by Andreas Bergmann


Book ID
113560244
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
62 KB
Volume
16
Category
Article
ISSN
0960-9822

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## Abstract Binding of tumor necrosis factor‐α (TNF‐α) to its receptor activates IKK complex, which leads to inducement of NF‐κB activity. Here we report that activation of Mpl ligand is also linked to IKK and NF‐κB activity. Mpl ligand, also known as thrombopoietin (TPO) or megakaryocyte growth an