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IKK/NF-κB signalling in chronic inflammation

✍ Scribed by Manolis Pasparakis


Book ID
116398867
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
110 KB
Volume
48
Category
Article
ISSN
1043-4666

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## Abstract Binding of tumor necrosis factor‐α (TNF‐α) to its receptor activates IKK complex, which leads to inducement of NF‐κB activity. Here we report that activation of Mpl ligand is also linked to IKK and NF‐κB activity. Mpl ligand, also known as thrombopoietin (TPO) or megakaryocyte growth an