Ifosfamide nephrotoxicity in paediatric cancer patients
β Scribed by M. S. Ashraf; J. Brady; F. Breatnach; P. F. Deasy; A. O'Meara
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 463 KB
- Volume
- 153
- Category
- Article
- ISSN
- 0340-6997
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π SIMILAR VOLUMES
Renal proximal tubule cell injury is an important side effect of the chemotherapeutic agent ifosfamide in humans. We investigated the effect of this medication on kidney function in rats. Animals received either 40 or 80 mg kg-' ifosfamide intraperitoneally daily for 3 days every 3 weeks for a total
## Abstract Nephrotoxicity is a frequent complication of treatment with ifosfamide in children. Although renal damage may be acute and reversible, chronic toxicity may develop with potentially serious consequences. Chronic nephrotoxicity due to ifosfamide may lead to a wide variety of subclinical a
## Purpose: This study was performed to describe prospectively the development and prognosis of severe ifosfamide-induced nephrotoxicity and to define the period of recommended renal follow-up after ifosfamide chemotherapy. ## Patients and methods: Renal function was followed in 75 patients after