Idiotypic and immunochemical differences of anti-DNA antibodies of a lupus patient during active and inactive disease
β Scribed by Ronsuke Suenaga; Marilyn Evans; Nabih I. Abdou
- Book ID
- 119485528
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 712 KB
- Volume
- 61
- Category
- Article
- ISSN
- 1090-2341
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Two common cross-reacting anti-DNA antibody idiotypes designated 1616 and 32/15, previously identified in the serum of patients who have systemic lupus erythematosus, were found in 24% and 7%, respectively, of 147 first-degree relatives. These findings imply that high-frequency germ-line genes exist
To examine autoantibodies present in patients with active systemic lupus erythematosus (SLE), sera, circulating immune comptexes (CIC), and antibodies purified on DNA-immunoadsorbent were tested by enzyme immunoassay. A panel of self-antigens, including DNA, histones (HIS), glomerular basal membrane