✦ LIBER ✦

Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist

✍ Scribed by Masaki Setoguchi; Shin Iimura; Yuuichi Sugimoto; Yoshiyuki Yoneda; Jun Chiba; Toshiyuki Watanabe; Fumihito Muro; Yutaka Iigo; Gensuke Takayama; Mika Yokoyama; Tomoe Taira; Misato Aonuma; Tohru Takashi; Atsushi Nakayama; Nobuo Machinaga

Book ID: 113495664
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 714 KB
Volume: 20
Category: Article
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2011.12.045

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

ChemInform Abstract: A Novel Synthetic A

ChemInform Abstract: A Novel Synthetic Approach to Very Late Antigen-4 Antagonist trans-4-[1-[ [2,5-Dichloro-4-(1-methyl-3-indolylcarboxyamide)phenyl]acetyl] -(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid (VIII) via tert-Butyl trans-[(4S)-Methoxy-(2S)-pyrrolidinylmethoxy] Cyclohexanecarboxylate (VI) as a Key Intermediate.

✍ Jun Chiba; Nobuo Machinaga 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

A Novel Synthetic Approach to Very Late Antigen-4 Antagonist trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxyamide)phenyl]acetyl]--(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid (VIII) via tert-Butyl trans-[(4S)-Methoxy-(2S)-pyrrolidinylmethoxy] Cyclohexanecarboxylate (VI) as

ChemInform Abstract: A Concise Synthesis

ChemInform Abstract: A Concise Synthesis of a Very Late Antigen-4 Antagonist trans-4-[1-[ [2,5-Dichloro-4-(1-methyl-3-indolylcarboxyamide)phenyl]acetyl] -(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid (V) via Reductive Etherification.

✍ Chiba, Jun; Muro, Fumihito; Setoguchi, Masaki; Machinaga, Nobuo 📂 Article 📅 2012 🏛 John Wiley and Sons ⚖ 31 KB

Metabolism of 7-Fluoro-6-(3,4,5,6-tetrah

Metabolism of 7-Fluoro-6-(3,4,5,6-tetrahydrophthalimido)-4- (2-propynyl)-2 H -1,4-benzoxazin-3(4 H )-one (S-53482) in Rat. 1. Identification of a Sulfonic Acid Type Conjugate

✍ Tomigahara, Yoshitaka; Matsui, Masayoshi; Matsunaga, Haruyuki; Isobe, Naohiko; K 📂 Article 📅 1999 🏛 American Chemical Society 🌐 English ⚖ 103 KB

Discovery Process and Pharmacological Ch

Discovery Process and Pharmacological Characterization of 2-( S )-(4-Fluoro-2-methylphenyl)piperazine-1-carboxylic Acid [1-( R )-(3,5-Bis-trifluoromethylphenyl)ethyl]methylamide (Vestipitant) as a Potent, Selective, and Orally Active NK 1 Receptor Antagonist

✍ Di Fabio, Romano; Griffante, Cristiana; Alvaro, Giuseppe; Pentassuglia, Giorgio; 📂 Article 📅 2009 🏛 American Chemical Society 🌐 English ⚖ 353 KB

ChemInform Abstract: Studies on Pyridone

ChemInform Abstract: Studies on Pyridonecarboxylic Acids. Part 4. Synthesis and Antibacterial Activity Evaluation of S-(-)- and R-(+)-6-Fluoro-1- methyl-4-oxo-7-(1-piperazinyl)-4H-(1,3)thiazeto(3,2-a)quinoline-3- carboxylic Acids.

✍ J. SEGAWA; K. KAZUNO; M. MATSUOKA; I. AMIMOTO; M. OZAKI; M. MATSUDA; Y. TOMII; M 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB

Identification of (3 R )-7-Hydroxy- N -(

Identification of (3 R )-7-Hydroxy- N -((1 S )-1-{[(3 R ,4 R )-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a Novel Potent and Selective Opioid κ Receptor Antagonist

✍ Thomas, James B.; Atkinson, Robert N.; Vinson, N. Ariane; Catanzaro, Jennifer L. 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 169 KB