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Identification of toxic alkaloids from the calcaratus subspecies of Lupinus arbustus

โœ Scribed by Hatfield, George M.; Yang, David J.; Ferguson, Paul W.; Keller, William J.


Book ID
125967676
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
571 KB
Volume
33
Category
Article
ISSN
0021-8561

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Acute toxicity of the major alkaloids of
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The seed of modern cultivars of Lupinus angustifolius normally contain less than 0.03% alkaloids. The acute oral LD, to rats of a pro rata mixture of the alkaloids of L. angustifolius seed was found to be 2279 mg/kg. For lupanine the LDS0 by oral administration was 1464 mg/kg and by intraperitoneal

The toxicity of seed extracts and their
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Seed extracts obtained from Lupinus albus and Lupinus angustifolius by treatment with 48% ethanol contained ca. 10% alkaloids (on a dry weight basis) and were non-toxic. Their acute toxicity ( L D ~~) in the mouse is > 4000 mgkg-' body wt. After fractionation, the extract from L. angustifolius seed