Acute toxicity of the major alkaloids of cultivated Lupinus angustifolius seed to rats

✍ Scribed by D. S. Petterson; Z. L. Ellis; D. J. Harris; Z. E. Spadek

• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 254 KB
• Volume: 7
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550070109

✦ Synopsis

The seed of modern cultivars of Lupinus angustifolius normally contain less than 0.03% alkaloids. The acute oral LD, to rats of a pro rata mixture of the alkaloids of L. angustifolius seed was found to be 2279 mg/kg. For lupanine the LDS0 by oral administration was 1464 mg/kg and by intraperitoneal injection 177 mg/kg. For 13-hydroxylupanine the LDSo by intraperitoneal injection was 199 mg/kg. Since these two alkaloids comprise about 85% of the total and are known to be rapidly cleared from the body it is suggested that the alkaloids in this species do not pose a health problem for man.