✦ LIBER ✦

The toxicity of seed extracts and their fractions from Lupinus angustifolius L. and Lupinus albus L.

✍ Scribed by M. Stobiecki; B. Blaszczyk; S. H. Kowalczyk-Bronisz; K. Gulewicz

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 456 KB
Volume: 13
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550130509

No coin nor oath required. For personal study only.

✦ Synopsis

Seed extracts obtained from Lupinus albus and Lupinus angustifolius by treatment with 48% ethanol contained ca. 10% alkaloids (on a dry weight basis) and were non-toxic. Their acute toxicity ( L D ~~) in the mouse is > 4000 mgkg-' body wt.

After fractionation, the extract from L. angustifolius seeds afforded several fractions with differing toxicities ( ~~~~7 5 0 4 0 0 0 mg kg-' body wt.). None of the fractions tested in vitro were toxic. The results obtained showed that, in spite of the alkaloids, other low-molecular-weight constituents present significantly modified the toxicity of the lupin extracts.

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