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Identification of three distinct regions of deletion on the long arm of chromosome 11 in childhood acute lymphoblastic leukemia

✍ Scribed by Takeuchi, Seisho; Cho, Steve K; Seriu, Taku; Koike, Michiaki; Bartram, Claus R; Reiter, Alfred; Schrappe, Martin; Takeuchi, Chise; Taguchi, Hirokuni; Koeffler, H Phillip


Book ID
110062513
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
118 KB
Volume
18
Category
Article
ISSN
0950-9232

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We have characterised a region of deletion on the long arm of chromosome 6 (6q) in six cases of acute lymphobiastic leukaemia, by fluorescence in situ hybridisation, using a series of YAC clones which map to 6q. Conventional cytogenetic analysis of four of these cases had been interpreted as showing

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## Abstract We have used fluorescence in situ hybridisation (FISH) with a series of yeast artificial chromosome (YAC) clones that map to the long arm of chromosome 6 (6__q__) to define the region(s) of deletion in seven cases of non‐Hodgkin's lymphoma (NHL), in which a deletion of 6q had been detec