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Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia

✍ Scribed by Dr. Lia P. Menasce; Vassilis Orphanos; Mauro Santibanez-Koref; John M. Boyle; Christine J. Harrison

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 340 KB
Volume: 10
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870100105

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✦ Synopsis

We have characterised a region of deletion on the long arm of chromosome 6 (6q) in six cases of acute lymphobiastic leukaemia, by fluorescence in situ hybridisation, using a series of YAC clones which map to 6q. Conventional cytogenetic analysis of four of these cases had been interpreted as showing terminal deletions of 6q. We demonstrated by FISH that in all cases the deletions were interstitial. D6S246 (6q16.3) was the only marker which was missing in all six cases, indicating a common region of deletion between the markers M6P I at 6q 14-1 5 and FYN at 6q2I. Our results suggest the presence of a tumour suppressor gene within this interval. Genes Chrom Cancer 10:26-29 (1994).

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