✦ LIBER ✦

Commonly deleted regions on the long arm of chromosome 21 in differentiated adenocarcinoma of the stomach

✍ Scribed by Ken Sakata; Gen Tamura; Satoshi Nishizuka; Chihaya Maesawa; Yasushi Suzuki; Takeshi Iwaya; Masanori Terashima; Kazuyoshi Saito; Ryoichi Satodate

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 93 KB
Volume: 18
Category: Article
ISSN: 1045-2257
DOI: 10.1002/(sici)1098-2264(199704)18:4<318::aid-gcc12>3.0.co;2-c

No coin nor oath required. For personal study only.

✦ Synopsis

During an allelotype analysis of differentiated adenocarcinoma of the stomach, we observed frequent loss of heterozygosity (LOH) on several chromosomes including the long arm of chromosome 21 (21q). Therefore, we analyzed DNA isolated from 45 tumors for LOH at 10 loci on 21q by using polymorphic microsatellite markers. In 20 (44%) of 45 tumors, we detected LOH at single or multiple loci on 21q. Deletion mapping of these 20 tumors revealed two separate commonly deleted regions. Our findings suggest that 21q contains at least two potential tumor suppressor genes which play crucial roles in the development of differentiated adenocarcinoma of the stomach.

📜 SIMILAR VOLUMES

Identification of three commonly deleted

Identification of three commonly deleted regions on chromosome arm 6q in human pancreatic cancer

✍ Tadayoshi Abe; Naohiko Makino; Toru Furukawa; Hong Ouyang; Mitsuhiro Kimura; Tos 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 102 KB 👁 2 views

Pancreatic cancer has one of the poorest prognoses among malignant diseases. To understand its molecular mechanisms, we studied allelic losses on the long arm of chromosome 6. Using 55 paired DNAs of tumors and their corresponding normal tissues and 30 microsatellite markers that spanned the entire

Frequent gain of copy number on the long

Frequent gain of copy number on the long arm of chromosome 20 in human pancreatic adenocarcinoma

✍ Shinichi Fukushige; Frederic M. Waldman; Mitsuhiro Kimura; Tadayoshi Abe; Toru F 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 194 KB 👁 1 views

We have used comparative genomic hybridization (CGH) to survey genomic regions with aberrant copy numbers of DNA sequences in pancreatic adenocarcinoma. In 12 cell lines and 6 primary tumors from 18 patients with pancreatic adenocarcinomas, highly frequent losses (.60%) were observed on chromosome a

Interstitial deletion of the long arm of

Interstitial deletion of the long arm of chromosome 10: Del(10)(q11.2q21)

✍ Holden, Jeanette J. A. ;MacDonald, E. Athen ;Opitz, John M. ;Reynolds, James F. 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 201 KB 👁 1 views

Paracentric inversion involving the long

Paracentric inversion involving the long arm of chromosome 9 resulting in deletion of abl gene

✍ Kleyman, Svetlana M.; Parekh, Aruna J.; Rodriguez, Abraham R.; Conte, Robert A.; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 116 KB 👁 1 views

We report on a new chromosomal finding in a newborn male with hypertelorism, apparently low-set malformed ears with patent canal, micrognathia with narrow higharched palate, bilateral webbing of neck with low posterior hairline, widely spaced nipples, and complex heart anomalies. Initially, what app

Smallest terminal deletion of the long a

Smallest terminal deletion of the long arm of chromosome 2 in a mildly affected boy

✍ Lin, Shuan-Pei ;Petty, Elizabeth M. ;Gibson, Lisa H. ;Inserra, Joann ;Seashore, 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 289 KB 👁 1 views

Gardner syndrome in a boy with interstit

Gardner syndrome in a boy with interstitial deletion of the long arm of chromosome 5

✍ Kobayashi, Tatsunori ;Narahara, Kouji ;Yokoyama, Yuji ;Ueyama, Satoshi ;Mohri, O 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 410 KB 👁 2 views