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Identification of the prion protein allotypes which accumulate in the brain of sporadic and familial Creutzfeldt-Jakob disease patients

✍ Scribed by Silvestrini, Maria Chiara; Cardone, Franco; Maras, Bruno; Pucci, Piero; Barra, Donatella; Brunori, Maurizio; Pocchiari, Maurizio


Book ID
109928595
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
612 KB
Volume
3
Category
Article
ISSN
1078-8956

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Polymorphisms of the prion protein gene
✍ Mirella Salvatore; Maurizio Genuardi; Rosella Petraroli; Carlo Masullo; Marco D' πŸ“‚ Article πŸ“… 1994 πŸ› Springer 🌐 English βš– 593 KB

Creutzfeldt-Jakob disease (CJD) is a transmissible neurodegenerative disorder characterized by the accumulation of the amyloid protein PrP in the CNS. Two coding polymorphisms of the PrP gene (PRNP) are a methionine (Met) to valine (Val) change at codon 129, and a deletion in the octapeptide coding