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Polymorphisms of the Prion Protein gene in italian patients with Creutzfeldt-Jakob disease

✍ Scribed by Mirella Salvatore; Maurizio Genuardi; Rosella Petraroli; Carlo Masullo; Marc D'Alessandro; Maurizio Pocchiari


Publisher
Springer
Year
1995
Tongue
English
Weight
31 KB
Volume
95
Category
Article
ISSN
0340-6717

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Polymorphisms of the prion protein gene
✍ Mirella Salvatore; Maurizio Genuardi; Rosella Petraroli; Carlo Masullo; Marco D' πŸ“‚ Article πŸ“… 1994 πŸ› Springer 🌐 English βš– 593 KB

Creutzfeldt-Jakob disease (CJD) is a transmissible neurodegenerative disorder characterized by the accumulation of the amyloid protein PrP in the CNS. Two coding polymorphisms of the PrP gene (PRNP) are a methionine (Met) to valine (Val) change at codon 129, and a deletion in the octapeptide coding