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Quantification of the vacuolation (spongiform change) and prion protein deposition in 11 patients with sporadic Creutzfeldt-Jakob disease

✍ Scribed by R. Armstrong; N. Cairns; P. Lantos


Publisher
Springer-Verlag
Year
2001
Tongue
English
Weight
139 KB
Volume
102
Category
Article
ISSN
0001-6322

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Polymorphisms of the prion protein gene
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Creutzfeldt-Jakob disease (CJD) is a transmissible neurodegenerative disorder characterized by the accumulation of the amyloid protein PrP in the CNS. Two coding polymorphisms of the PrP gene (PRNP) are a methionine (Met) to valine (Val) change at codon 129, and a deletion in the octapeptide coding