Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ
✍ Scribed by Bruno A. Bernard; Jean-Michel Bernardon; Chantal Delescluse; Bernard Martin; Marie-Cécile Lenoir; Jean Maignan; Bruno Charpentier; William R. Pilgrim; Uwe Reichert; Braham Shroot
- Book ID
- 115765099
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 420 KB
- Volume
- 186
- Category
- Article
- ISSN
- 0006-291X
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## Abstract The first step in retinoid action is binding to their nuclear receptors. Therefore, characterization of binding characteristics of retinoids is of major importance. Human retinoic acid receptors α (hRARα), hRARβ, and mouse RARγ (mRARγ) were expressed heterologously in __Escherichia coli
Retinoids modulate several cell functions and especially inhibit the growth of a wide variety of cells including breast cancer. Retinoic acid receptor-gamma (RAR-gamma) has been shown to mediate the antiproliferative activity of retinoids. To further test this hypothesis we examined the effects of d