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Identification of short-chain α-hydroxyaldehydes produced by lipid peroxidation in bovine liver

✍ Scribed by Angelika Loidl; Gerhard Spiteller

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
291 KB
Volume
28
Category
Article
ISSN
1076-5174

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✦ Synopsis

Abstract

A method to detect short‐chain α‐hydroxyaldehydes in mammalian tissues is described. Aldehydes or their masked precursor molecules are converted into dithiolane derivatives. These are separated by thin‐layer chromatography and registered by multiple ion monitoring after trimethylsilylation. Fragmentation of 2‐(1′‐trimethylsilyloxy)‐1,3‐dithiolanes was studied by using electron impact ionization.

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