Short communication: Possible involvement of lipid peroxidation in the inhibition of type I iodothyronine 5′-monodeiodinase activity by lead in chicken liver
✍ Scribed by S. S. Chaurasia; P. Gupta; P. K. Maiti; A. Kar
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 45 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0260-437X
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✦ Synopsis
The possible involvement of lipid peroxidation (LPO) in the lead-induced inhibition of type I iodothyronine 5′-monodeiodinase activity (5′-D) has been worked out in chicken liver. Lead nitrate (1.5 mg per bird per day) for 30 days increased the lipid peroxidative process with a concomitant decrease in 5′-D activity in chicken liver. Also, a significant decrease in serum triiodothyronine (T 3 ) concentration and an increase in serum thyroxine (T 4 ) concentration were observed. The data suggest that lead-induced inhibition of type I 5′-D activity in chicken liver is mediated through the lipid peroxidative process.