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Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines

✍ Scribed by Tsao, Hensin; Zhang, Xue; Benoit, Eric; Haluska, Frank G


Book ID
110061381
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
563 KB
Volume
16
Category
Article
ISSN
0950-9232

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## Abstract A majority of malignant melanomas harbor an oncogenic mutation in either __BRAF__ or __NRAS__. If __BRAF__ and __NRAS__ transform melanoma cells by a similar mechanism, then additional genetic aberrations would be similar (or random). Alternatively, distinct mutation‐associated changes