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Identification of Previously Unrecognized Antiestrogenic Chemicals Using a Novel Virtual Screening Approach

✍ Scribed by Wang, Ching Y.; Ai, Ni; Arora, Sonia; Nagarajan, Karthigeyan; Zauhar, Randy; Young, Douglas; Welsh, William J.


Book ID
127288717
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
248 KB
Volume
19
Category
Article
ISSN
0893-228X

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We report the identification of a novel NR2B-selective NMDAR antagonist with an original scaffold, LSP10-0500. This compound was identified by a virtual high-throughput screening approach on the basis of a quantitative pharmacophore model of NR2B-specific NMDAR antagonists. A SAR study around LSP10-