Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach

✍ Scribed by Laetitia Mony; Nicolas Triballeau; Pierre Paoletti; Francine C. Acher; Hugues-Olivier Bertrand

• Book ID: 104004650
• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 1007 KB
• Volume: 20
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.07.043

✦ Synopsis

We report the identification of a novel NR2B-selective NMDAR antagonist with an original scaffold, LSP10-0500. This compound was identified by a virtual high-throughput screening approach on the basis of a quantitative pharmacophore model of NR2B-specific NMDAR antagonists. A SAR study around LSP10-0500 is also described.