Identification of a novel NR2B-selective
Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach
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Laetitia Mony; Nicolas Triballeau; Pierre Paoletti; Francine C. Acher; Hugues-Ol
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Article
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2010
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Elsevier Science
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English
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We report the identification of a novel NR2B-selective NMDAR antagonist with an original scaffold, LSP10-0500. This compound was identified by a virtual high-throughput screening approach on the basis of a quantitative pharmacophore model of NR2B-specific NMDAR antagonists. A SAR study around LSP10-