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Identification of Novel Adenosine A 2A Receptor Antagonists by Virtual Screening

✍ Scribed by Langmead, Christopher J.; Andrews, Stephen P.; Congreve, Miles; Errey, James C.; Hurrell, Edward; Marshall, Fiona H.; Mason, Jonathan S.; Richardson, Christine M.; Robertson, Nathan; Zhukov, Andrei; Weir, Malcolm


Book ID
118168226
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
277 KB
Volume
55
Category
Article
ISSN
0022-2623

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Identification of a novel NR2B-selective
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We report the identification of a novel NR2B-selective NMDAR antagonist with an original scaffold, LSP10-0500. This compound was identified by a virtual high-throughput screening approach on the basis of a quantitative pharmacophore model of NR2B-specific NMDAR antagonists. A SAR study around LSP10-