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Identification of Novel Cannabinoid CB1 Receptor Antagonists by Using Virtual Screening with a Pharmacophore Model

โœ Scribed by Wang, Hongwu; Duffy, Ruth A.; Boykow, George C.; Chackalamannil, Samuel; Madison, Vincent S.


Book ID
118246971
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
446 KB
Volume
51
Category
Article
ISSN
0022-2623

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We report the identification of a novel NR2B-selective NMDAR antagonist with an original scaffold, LSP10-0500. This compound was identified by a virtual high-throughput screening approach on the basis of a quantitative pharmacophore model of NR2B-specific NMDAR antagonists. A SAR study around LSP10-