Identification of Novel, Water-Soluble, 2-Amino- N -pyrimidin-4-yl Acetamides as A 2A Receptor Antagonists with In Vivo Efficacy
✍ Scribed by Slee, Deborah H.; Zhang, Xiaohu; Moorjani, Manisha; Lin, Emily; Lanier, Marion C.; Chen, Yongsheng; Rueter, Jaimie K.; Lechner, Sandra M.; Markison, Stacy; Malany, Siobhan; Joswig, Tanya; Santos, Mark; Gross, Raymond S.; Williams, John P.; Castro-Palomino, Julio C.; Crespo, María I.; Prat, Maria; Gual, Silvia; Díaz, José-Luis; Wen, Jenny; O’Brien, Zhihong; Saunders, John
- Book ID
- 120323143
- Publisher
- American Chemical Society
- Year
- 2008
- Tongue
- English
- Weight
- 218 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0022-2623
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## Abstract 2‐(4‐Methoxyphenyl)‐__N__‐(4‐methylbenzyl)‐__N__‐(1‐methylpiperidin‐4‐yl)acetamide (AC90179, **4**), a highly potent and selective competitive 5‐HT~2A~ antagonist, was labeled by [^11^C]‐methylation of the corresponding desmethyl analogue **5** with [^11^C]methyl triflate. The precursor
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