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Discovery of 1-(2,4-Dichlorophenyl)- N -(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1 H -pyrazole-3-carboxamide as a Novel Peripherally Restricted Cannabinoid-1 Receptor Antagonist with Significant Weight-Loss Efficacy in Diet-Induced Obese Mice

✍ Scribed by Chang, Chun-Ping; Wu, Chien-Huang; Song, Jen-Shin; Chou, Ming-Chen; Wong, Ying-Chieh; Lin, Yinchiu; Yeh, Teng-Kuang; Sadani, Amit A.; Ou, Ming-Hung; Chen, Kun-Hung; Chen, Pei-Hsuan; Kuo, Po-Chu; Tseng, Chen-Tso; Chang, Kuei-Hua; Tseng, Shi-Liang; Chao, Yu-Sheng; Hung, Ming-Shiu; Shia, Kak-Shan

Book ID: 121408619
Publisher: American Chemical Society
Year: 2013
Tongue: English
Weight: 834 KB
Volume: 56
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm401158e

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