Identification of lipopolysaccharide binding site on high molecular weight kininogen
β Scribed by R. Perkins; M. Dinh Ngo; F. Mahdi; Z. Shariat-Madar
- Book ID
- 116296126
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 152 KB
- Volume
- 366
- Category
- Article
- ISSN
- 0006-291X
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Human low-molecular-weight kininogen (LK) was shown by fluorescence titration to bind two molecules of cathepsins L and S and papain with high affinity. By contrast, binding of a second molecule of cathepsin H was much weaker. The 2:1 binding stoichiometry was confirmed by titration monitored by los
Synthetic vascular grafts implanted into humans fail to develop a complete endothelial lining. In previous studies, we have shown that high-molecular-weight kininogens (HMWK) adsorb to the surfaces of biomaterials. In addition, it has been demonstrated that these proteins modulate cellular function.