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Identification of immunodominant T cell epitopes of pyruvate dehydrogenase complexes in primary biliary cirrhosis

✍ Scribed by Shimoda, S.; Nakamura, M.; Hayashida, K.; Kudo, J.; Ishibashi, H.; Niho, Y.


Book ID
122416179
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
99 KB
Volume
1
Category
Article
ISSN
0928-4680

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Primary biliary cirrhosis (PBC) is an autoimmune condition that results in destruction of the intrahepatic biliary epithelial cells and is characterized by autoantibodies to pyruvate dehydrogenase complex (PDC). The portal tract T-cell infiltrate and up-regulation of HLA class I, HLA class 11, and c