Is anti-pyruvate dehydrogenase complex a predictor of the development of primary biliary cirrhosis?

The pyruvate dehydrogenase complex as a

The pyruvate dehydrogenase complex as a target autoantigen in primary biliary cirrhosis

✍ Akiyoshi Nishio; Ross Coppel; Hiromi Ishibashi; M.Eric Gershwin 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 156 KB

T-cell responses to the components of py

T-cell responses to the components of pyruvate dehydrogenase complex in primary biliary cirrhosis

✍ David E. J. Jones; Jeremy M. Palmer; Oliver F. W. James; Stephen J. Yeaman; Marg 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 903 KB

Primary biliary cirrhosis (PBC) is an autoimmune condition that results in destruction of the intrahepatic biliary epithelial cells and is characterized by autoantibodies to pyruvate dehydrogenase complex (PDC). The portal tract T-cell infiltrate and up-regulation of HLA class I, HLA class 11, and c

Detection of anti-pyruvate dehydrogenase

Detection of anti-pyruvate dehydrogenase complex antibody in primary biliary cirrhosis by an enzyme-linked immunosorbent assay

✍ Tsuruya, Takashi 📂 Article 📅 1990 🏛 Springer-Verlag 🌐 English ⚖ 626 KB

Enzyme inhibitory autoantibodies to pyru

Enzyme inhibitory autoantibodies to pyruvate dehydrogenase complex in primary biliary cirrhosis: Applications of a semiautomated assay

✍ Khay-Lin Teoh; Merrill J. Rowley; Helen Zafirakis; E. Rolland Dickson; Russell H 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 575 KB

Sera from patients with primary biliary cirrhosis inhibit the activity of the mitochondrial pyruvate dehydrogenase complex. We utilized this effect to develop a simple, miniaturized, semiautomated spectrophotometric assay as a diagnostic aid. The sera studied were from 71 patients with primary bilia

In situ nucleic acid hybridization of py

In situ nucleic acid hybridization of pyruvate dehydrogenase complex-E2 in primary biliary cirrhosis: Pyruvate dehydrogenase complex-E2 messenger RNA is expressed in hepatocytes but not in biliary epithelium

✍ K. Harada; J. Van de Water; P. S. Leung; R. L. Coppel; Y. Nakanuma; M. E. Gershw 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 653 KB

Pyruvate dehydrogenase-E2, or a cross-reactive molecule, has been shown by a variety of immunohistochemical methods to be present in increased amounts in biliary epithelial cells (BEC) in primary biliary cirrhosis (PBC). In this study, to further understand the nature of the immunoreactive molecule

In situ nucleic acid hybridization of py

In situ nucleic acid hybridization of pyruvate dehydrogenase complex-E2 in primary biliary cirrhosis: Pyruvate dehydrogenase complex-E2 messenger RNA is expressed in hepatocytes but not in biliary epithelium

✍ K Harada; J Van de Water; PS Leung; RL Coppel; Y Nakanuma; ME Gershwin 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 661 KB