The pyruvate dehydrogenase complex as a target autoantigen in primary biliary cirrhosis
โ Scribed by Akiyoshi Nishio; Ross Coppel; Hiromi Ishibashi; M.Eric Gershwin
- Book ID
- 111719751
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 156 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1521-6918
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๐ SIMILAR VOLUMES
Primary biliary cirrhosis (PBC) is an autoimmune condition that results in destruction of the intrahepatic biliary epithelial cells and is characterized by autoantibodies to pyruvate dehydrogenase complex (PDC). The portal tract T-cell infiltrate and up-regulation of HLA class I, HLA class 11, and c
Sera from patients with primary biliary cirrhosis inhibit the activity of the mitochondrial pyruvate dehydrogenase complex. We utilized this effect to develop a simple, miniaturized, semiautomated spectrophotometric assay as a diagnostic aid. The sera studied were from 71 patients with primary bilia