Autoreactive liver-infiltrating T cells in primary biliary cirrhosis recognize inner mitochondrial epitopes and the pyruvate dehydrogenase complex
✍ Scribed by H. Löhr; B. Fleischer; G. Gerken; S.J. Yeaman; K.-H. Meyer zum Büschenfelde; M. Manns
- Book ID
- 118566247
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 536 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0168-8278
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Primary biliary cirrhosis (PBC) is an autoimmune condition that results in destruction of the intrahepatic biliary epithelial cells and is characterized by autoantibodies to pyruvate dehydrogenase complex (PDC). The portal tract T-cell infiltrate and up-regulation of HLA class I, HLA class 11, and c
Autoantibodies to the human hepatic asialoglycoprotein receptor have been found in nearly 50% of the sera of patients with autoimmune chronic active hepatitis and in 15% of patients with primary biliary cirrhosis. In this study we demonstrate that the human hepatic asialoglycoprotein receptor is als