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No role for autoreactive antibody in the breakdown of T-cell tolerance to pyruvate dehydrogenase complex, the autoantigen in primary biliary cirrhosis: Amanda J Robe, Jeremy M Palmer, John A Kirby, David E Jones, Centre for Liver Research, University of Newcastle, Newcastle-upon-Tyne Uk

Book ID: 118689161
Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 204 KB
Volume: 34
Category: Article
ISSN: 0270-9139
DOI: 10.1053/s0270-9139(00)82912-2

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The key immunological event in the pathogenesis of the autoimmune liver disease primary biliary cirrhosis is breakdown of T-cell self-tolerance to pyruvate dehydrogenase complex (PDC). The mechanism resulting in this breakdown of tolerance remains unclear. Mice exposed to self-PDC mount no immune re