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Exploration of the immunogenicity of the primary biliary cirrhosis autoantigen pyruvate dehydrogenase complex: David E Jones, Amanda J Robe, Jeremy M Palmer, John A Kirby, Centre for Liver Research, University of Newcastle, Newcastle-upon-Tyne Uk


Book ID
118689110
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
195 KB
Volume
34
Category
Article
ISSN
0270-9139

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โœ Amanda J. Robe; John A. Kirby; David E. J. Jones; Jeremy M. Palmer ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 384 KB ๐Ÿ‘ 1 views

The key immunological event in the pathogenesis of the autoimmune liver disease primary biliary cirrhosis is breakdown of T-cell self-tolerance to pyruvate dehydrogenase complex (PDC). The mechanism resulting in this breakdown of tolerance remains unclear. Mice exposed to self-PDC mount no immune re

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The autoimmune liver disease primary biliary cirrhosis (PBC) is characterized by the breakdown of normal immune self tolerance to pyruvate dehydrogenase complex (PDC). How tolerance is broken to such a central and highly conserved self antigen in the initiation of autoimmunity remains unclear. One p